Proteomelab ™ Igy Proteome Partitioning Solutions.
Of particular importance for low abundance, proteome-based biomarker discovery in serum, plasma, CSF of other biofluids, we offer 12-plexed IgY-based immunoaffinity solutions for primates and 7-plexed solutions for rodents. Single component IgY columns are also available. Our solutions include hardware, software and consumables consisting of spin columns, medium capacity LC columns and High-Capacity LC columns, able to handle up to 250 µL rat serum or plasma per cycle. It is an important first step in the advanced proteomic sample preparation of biofluids.
ProteomeLab™ PF 2D Protein Fractionation System
The ProteomeLab PF 2D Protein Fractionation System meets the challenge of separating and detecting proteins with an automated, two-dimensional frantionation process (in liquid phase), that resolves proteins by isoelectric point in the first dimension. This system offers reproducible fractionation and top-down proteomics profiling from 1-5 mg of protein. Samples are divided into 700-1,200 liquid phase fractions in 96-well plates consisting of intact proteins ready for mass spectrometry, immunoassays or other analytical methods.
ProteomeLab™ PA 800 Protein Characterization System
The ProteomeLab PA 800 -- and all of our ProteomeLab offerings -- are designed to help to serve as an extension of your thinking, making it easier for you to do your best science, your way. That means you get a complete solution that puts meaningful, actionable information into your hands, quickly and easily.
By taking full advantage of our expertise in both capillary electrophoresis and automation technologies, the ProteomeLab PA 800 delivers a comprehensive in-solution protein characterization (protein electrophoresis) system designed to optimize proteomics discovery.
The ProteomeLab PA 800 resolves and quantifies proteins by their isolectric point and molecular weight, generates high-resolution peptide maps and carbohydrate profiles and provides front-end separation to mass spectrometry.
The ProteomeLab PA 800 Protein Characterization System is designed to facilitate accurate analysis of protein purity, heterogeneity and identity. By utilizing optimized chemistry and characterization methods in addition to integrated automation, the PA 800 allows for the simplified characterization of protein MW and charge heterogeneity as well as the analysis of carbohydrates. Controls built into the software enable compliance with 21 CFR Part 11.
Liquid Chromatography
System Gold® HPLC offers versatility for the analysis of peptides and proteins for the wide range of separation modes and associated mobile phases you require. In addition, automated column cleanup, system shutdown and step elution chromatography are standard on every system. Flow rates from microbore to 30 mL/min are available, in addition to stainless steel and complete PEEK flow paths.
ProteomeLab™ XL-A/XL-I Protein Characterization System
An important component of lead optimization is the ability to evaluate a drug candidate under concentrated "shelf-life" conditions before it moves into expensive preclinical or clinical trials. The ProteomeLab XL-A/XL-I functions over a wide range of concentration, temperature, ionic strength and pH, delivering more thorough characterization than other methods.
Our unique operating methodology measures the relative change in the distribution of molecular weights, providing an efficient way to measure heterogeneity, stoichiometry and self-associating systems.
Because the ProteomeLab XL-A/XL-I's measurements are based on the first principles of thermodynamics and hydrodynamics, no standards or calibrations are required. As a result, you spend less time on setup, and more time on discovery.
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