Beckman Coulter, Inc. is a leading manufacturer of biomedical testing instrument systems, tests and supplies that simplify and automate laboratory processes. Spanning the biomedical testing continuum—from pioneering medical research and clinical trials to laboratory diagnostics and point-of-care testing—Beckman Coulter's 200,000 installed systems provide essential biomedical information to enhance health care around the world. The company, based in Fullerton, Calif., reported 2007 annual sales of $2.76 billion with more than 78 percent of this amount generated by recurring revenue from supplies, test kits and services.  Beckman Coulter's Executive Officers
"I feel very fortunate to be given the chance to lead this company. Beckman Coulter has one of the best names in the biomedical testing industry, a legacy of innovation and integrity, a highly capable team of employees and the financial strength to make significant investments." "I am confident that we are on the threshold of great achievement as we embrace the challenge to save lives and improve the economics of health care." -- Scott Garrett Scott Garrett - Chairman, President and Chief Executive Officer |
Rabu, 03 Desember 2008
Beckman Coulter Company Profile
GENERAL RESEARCH TOOLS
Spectrophotometry
The DU® Series Spectrophotometers feature the DU 700 and DU 800 systems. The easy to use DU 700 system is designed to address routine applications at an affordable price. The DU 800 system offers exclusive micro-focused beam technology, which delivers the full energy of the beam to microsamples-using a 50 µL microcell, for highly accurate measurement of microvolume samples. Plus, the DU 800 Series software enables compliance with 21 CFR Part 11.
Also available for the DU 800 and DU 730 spectrophotometers is the nanoVette microliter measurement cell. Ideal for DNA and protein applications, the cuvette-sized nanoVette accepts sample sizes as small as 0.7 µL and is offered with interchangeable 0.2 mm and 1 mm path lengths.
DU® Series 700 UV/Vis Scanning Spectrophotometer
DU® 800 UV/Visible Spectrophotometer
Liquid Scintillation
The LS 6500 Scintillation Counter provides the highest spectral resolution and achieves accurate results with H Number Plus, our patented external quench monitor. The system can be easily customized to meet your specific requirements. Plus, it is ideal for Luciferase, Swipe and Receptor Binding Assays.
LS 6500 Liquid Scintillation Counter
Electrochemistry
Dr. Arnold Beckman’s invention of the pH meter in 1935 allows Beckman Coulter to bring over 70 years of experience and innovation to the field of pH measurements. Our pH meters provide quick, complete and precise pH temperature mV, relative mV, ORP and concentration (ISE) measurements. The product line meets all requirements in research, pharmaceutical, chemical and environmental applications.
F® 200 Series Handheld pH Meters
F 260 pH / Temp / mV Meter with RS-232 Interface and Data Storage
F 250 pH / Temp / mV Meter
F 240 pH / Temp Meter
F® 200 Series Waterproof Handheld pH Meters
F 295 pH / Temp / mV / ISE Meter with RS-232 Interface and Data Storage
F 265 pH / Temp / mV Meter with RS-232 Interface and Data Storage
F 255 pH / Temp / mV Meter
F® 300 Series Benchtop pH Meters
F 390 pH / Temp / mV / ISE Meter with RS-232 Interface and Data Storage
F 360 pH / Temp / mV Meter with RS-232 Interface and Data Storage
F 350 pH / Temp / mV Meter
F 340 pH / Temp Meter
F® 600 Series High-Performance pH Meters
F 690 pH / Temp / mV / ISE Meter
F 660 pH / Temp / mV Meter
CENTRIFUGATION
Celebrating our 60 years of global leadership in centrifugation, Beckman Coulter designs, manufactures, sells and services a complete line of centrifuge systems, By offering unique rotors, innovative bottles, tubes and accessories, coupled with advanced centrifugation software, Beckman Coulter delivers powerful centrifugation solutions to laboratory science. Our two highest performance families are the Optima™ Series Ultracentrifuge, offered in both floor and benchtop models, and the Avanti®Series High-Performance and High-Capacity Centrifuges. The exciting new centrifuge products are the New Optima MAX-XP benchtop ultracentrifuge and the Microfuge® 16 microcentrifuge.
Benchtop Centrifugation
The Allegra and Microfuge® Series benchtop centrifuges provide high-performance and versatility. Designed specifically with key applications mind, we offer the Allegra X-15R with unique cell culture flask adapters and exclusive ARIES™ rotor technology, which detects and corrects opposing load imbalances up to 50g; Allegra X-22 Series Multipurpose Centrifuge (extremely compact, only 18”/45.72 cm wide); Allegra 25R High-Performance DNA Benchtop Centrifuge; and the Allegra 64R High-Speed Benchtop Centrifuge.
Allegra® X-15R Benchtop Centrifuge
Allegra® X-12 Series Benchtop Centrifuges
Allegra® X-22 Series Benchtop Centrifuge
Allegra® 25R Refrigerated Benchtop Centrifuge
Allegra® 64R High-Speed Refrigerated Benchtop Centrifuge
Microcentrifugation
The Microfuge 16 spins quitly at 16,163x g for last pelleting or isolation of DNA, RNA, proteins and viruses. The Microfuge 18 offers powerful g-forces for last pelleting and the Microfuge 22R offers high g-forces with a wide variety of rotors and maintains samples at 40C.
Microfuge® 16 Microcentrifuge
Microfuge® 18 Microcentrifuge
Microfuge® 22R Refrigerated Microcentrifuge
Ultracentrifugation
The Optima L-XP Series Ultracentrifuges feature a sophisticated on-board computer with powerful eXPert™ software and easy to use touch screen control. The eXPert software provides optimized run methods, run simulation software, calculation tools, rotor and tube catalog, automatic run records and more. These models include the Optima L-100XP and the Optima L-80 XP.
The new Optima MAX-XP benchtop ultracentrifuge delivers fast run times with up to 150,000 RPM (2,500 revolutions per second) and is exceptionally quiet-producing only half the sound output of other models. The user interface is intuitive and customizable with control via a full-clor touch screen. Optional remote monitoring and control of the system is also available. Not only does the Optima MAX-XP fit inside a standard biosafety hood, but it can be ordered with HEPA filtration for enhanced safety.
The Optima™ Series ultracentrifuges for separation or preparation of proteins, lipoproteins, plasmid DNA, RNA, subcellular organelles and viruses.
High-Performance and High-Capacity
The Avanti J Series High-Performance and High-Capacity Centrifuges deliver high-throughput and versatility to laboratory research. From high g-force micro-plate applications to 6-liter runs, the Avanti J-26 XP is a very versatile floor centrifuge. The Avanti J-30I performs sub cellular separations in either swinging-bucket or fixed-angle rotors with g-forces over 100,000 x g and the small footprint of the Avanti J-HC is a high-capacity, high-throughput bioprocessing centrifuge capable of rapidly processing three to nine liters per run.
Capillary Electrophoresis
Beckman Coulter is the Industry leader in CE technologies and tools. Capillary electrophoresis can be an effective replacement for slab gel electrophoresis and a complement and alternative to HPLC. Our developments encompass hardware, software and chemistries. Our CE systems are used for therapeutic protein characterization, ion analysis, chiral analysis, basic drugs, nucleic acid purity and more.
P/ACE™ MDQ
The P/ACE™ MDQ Series are automated, programmable capillary electrophoresis systems designed to perform fast separations from complex samples. Separations occur in a capillary, which is housed in an interchangeable cartridge with circulating liquid coolant, for efficient temperature control. This finely regulated temperature control allows the use of high-ionic-strength buffers and large-bore capillaries necessary for analyzing difficult samples. With CE, methods are faster to develop, easier to validate and less expensive to run. However, specialized system designs are recommended to optimize performance for different applications.
AUTOMATED SOLUTIONS
Biomek® 3000 Laboratory Automation Workstation
The Biomek 3000 Laboratory Automation Workstation offers a flexible platform within a compact footprint. Our dedicated applications experts create automated solutions for a wide variety of commercially available kits. With Biomek software, it’s easy to configure any application to meet your specific needs.
Biomek® NXP Laboratory Automation Workstation
By incorporating a wide range of next-generation features into a small footprint design, Biomek NXP sets the standard for flexible laboratory solutions. It puts every aspect of liquid handling – including pipetting, dilution, dispensing and integration – into a single, automated system that is as powerful as it is efficient and economical. All while offering unprecedented options for changing needs. Combined with robust Biomek Software and our ongoing applications development, Biomek NXP is bringing new possibilities to life.
Biomek® FXP Laboratory Automation Workstation
The Biomek FXP is the latest entry in the Biomek line. With an up-to-date hardware design for greater positional accuracy and increased robustness, it can meet the needs of just about any application. It can be configured with either one or two pipetting pods. With its large deck capacity, the Biomek FXP sets the standard for flexible laboratory solutions to meet your changing needs. It puts every aspect of liquid handling – including pipetting, dilution, dispensing and integration – into a single, automated system that is as powerful and flexible as it is efficient and economical. Combined with the proven Biomek Software and our ongoing applications development, Biomek FXP is bringing new possibilities to life.
The Biomek FXP continuum starts with a single-pod system. Equip the high-capacity deck with Automated Labware Positioners (
ADMETox Workstation
Early drug discovery ADME toxicity assays, such as fast Caco-2 screens, can help in rejecting test compounds that lack good pharmaceutical profiles. A cost-effective high-throughput method, PAMPA
Biomek® Assay Workstation
Whether your assay of choice is a heterogeneous or homogeneous assay, the Biomek® Assay Workstation is designed to provide you all the functional components you need to perform your antibody-based immunoassay or cell-based assay. The Biomek FXP or NXP, at the heart of the Biomek Assay Workstation provides you with the timed delivery of multiple reagents (capture and detection of antibodies and cells), scheduled incubation of plates (room temperature or elevated temperatures are available on-board), scheduled wash steps (96-or 384 well plate washers are available on-board) and detection of reaction endpoints (fluorescence, absorbance, fluorescence polarization, time-resolved fluorescence, and luminescence are available on-board). The Biomek Assay Workstation features the new and powerful SAMI® Workstation EX software. Building on our long tradition of intuitive and flexible software, SAMI Workstation EX provides researchers with complete automation control. The Biomek Assay Workstation is designed to process your assay from start to finish in complete walk-away mode. The Biomek Assay Workstation was designed to allow you to perform your assays your way.
- Ensure system flexibility
- Complete automation solutions with on-deck integrations
- Streamline operations with SAMI Workstation EX software
- Address 21 CFR Part 11 needs
- Windows XP Operating Environment
BioRAPTR™ FRD
The BioRAPTR FRD workstation is an automated non-contact dispenser for low volume 384-well, 1536-well, and 3456-well plates. This workstation is the next generation Flying Reagent Dispenser™ (FRD). It produces highly accurate and precise dispensing across a volume range of 100 nL - 60 µL without cross-contamination, fully supporting integrated high-throughput screening, stand-alone assay development applications, and reagent additions applications in pharmacogenomic research. Key to its elegant design is a patented dispense head that utilizes four independent fluid pathways. The BioRAPTR FRD delivers reliable, high-quality performance with remarkably low dead volumes over an adjustable dispensing range.
PARADIGM™ Detection Platform
The PARADIGM Detection Platform features a selection of read-mode optimized detection cartridges that can be interchanged in less than five minutes to meet different assay needs. A detection cartridge includes all optical components and the light source required for a read mode. It is the first user-upgradable and configurable multimode reader, ideal for labs with multiple users and applications. The sensitive, high-throughput detector reads on the fly, in formats from to 1536 wells.
DTX 800/880 Series Multimode Detectors
Microplate Reader for Performing Fluorescence, Luminescence and Absorbance (UV and Visible) Measurements
The DTX 800/880 Series Multimode Detectors provide unmatched value and flexibility for a variety of application and automation needs, capable of performing:
- Fluorescence detection, time-resolved fluorescence, and fluorescence polarization
- Luminescence detection (glow luminescence)
- Absorbance detection in the visible range (340 nm to 650 nm, DTX 800) or UV and visible range (230 nm to 750 nm, DTX 880)
- Scan measurement types: endpoint, kinetic, multiple wavelength, linear scan and area scan
- Linear shaking (DTX 800)
- Orbital shaking (DTX 880)
The DTX Series can operate as standalone instruments or can be integrated seamlessly with Beckman Coulter's Biomek® Laboratory Automation Workstations. The DTX Series is ideal for a broad range of Systems Biology applications, including drug discovery, genomics, proteomics and cell-based research. The unique optics design (patents pending) ensures precise performance and sensitivity across all detection modes. The instruments facilitate easy integration with automated liquid handling systems via a choice of plate loading options. These include an extra-wide plate access door, and the ability to accept plates in portrait or landscape formats. In addition, the detectors' intuitive software platform provides instrument control and easy protocol development, as well as compatibility with Beckman Coulter's Biomek software program.
The DTX Series of detectors includes:
- DTX 800 Multimode Detector
The DTX 800 features fluorescence intensity (top reading), absorbance (visible) and glow luminescence for 96- to 384-well plates, as well as linear and orbital shaking. Users can program endpoint, kinetic, multiple wavelength, linear scan and area scan measurement types. Easily accessible six-position filter slides enable wavelength selection from 340 nm to 650 nm. - DTX 880 Multimode Detector
The DTX 880 features fluorescence intensity (top and bottom reading), time-resolved fluorescence, fluorescence polarization, absorbance (UV and visible), glow luminescence and temperature control for 6-384-well plates. In addition, the instrument also features linear and orbital shaking, plus temperature control. Users can program endpoint, kinetic, multiple wavelength, linear scan and area scan measurement types. Easily accessible six-position filter slides enable wavelength selection from 230 nm to 750 nm.
PROTEOMICS
Proteomelab ™ Igy Proteome Partitioning Solutions.
Of particular importance for low abundance, proteome-based biomarker discovery in serum, plasma, CSF of other biofluids, we offer 12-plexed IgY-based immunoaffinity solutions for primates and 7-plexed solutions for rodents. Single component IgY columns are also available. Our solutions include hardware, software and consumables consisting of spin columns, medium capacity LC columns and High-Capacity LC columns, able to handle up to 250 µL rat serum or plasma per cycle. It is an important first step in the advanced proteomic sample preparation of biofluids.
ProteomeLab™ PF 2D Protein Fractionation System
The ProteomeLab PF 2D Protein Fractionation System meets the challenge of separating and detecting proteins with an automated, two-dimensional frantionation process (in liquid phase), that resolves proteins by isoelectric point in the first dimension. This system offers reproducible fractionation and top-down proteomics profiling from 1-5 mg of protein. Samples are divided into 700-1,200 liquid phase fractions in 96-well plates consisting of intact proteins ready for mass spectrometry, immunoassays or other analytical methods.
ProteomeLab™ PA 800 Protein Characterization System
The ProteomeLab PA 800 -- and all of our ProteomeLab offerings -- are designed to help to serve as an extension of your thinking, making it easier for you to do your best science, your way. That means you get a complete solution that puts meaningful, actionable information into your hands, quickly and easily.
By taking full advantage of our expertise in both capillary electrophoresis and automation technologies, the ProteomeLab PA 800 delivers a comprehensive in-solution protein characterization (protein electrophoresis) system designed to optimize proteomics discovery.
The ProteomeLab PA 800 resolves and quantifies proteins by their isolectric point and molecular weight, generates high-resolution peptide maps and carbohydrate profiles and provides front-end separation to mass spectrometry.
The ProteomeLab PA 800 Protein Characterization System is designed to facilitate accurate analysis of protein purity, heterogeneity and identity. By utilizing optimized chemistry and characterization methods in addition to integrated automation, the PA 800 allows for the simplified characterization of protein MW and charge heterogeneity as well as the analysis of carbohydrates. Controls built into the software enable compliance with 21 CFR Part 11.
Liquid Chromatography
System Gold® HPLC offers versatility for the analysis of peptides and proteins for the wide range of separation modes and associated mobile phases you require. In addition, automated column cleanup, system shutdown and step elution chromatography are standard on every system. Flow rates from microbore to 30 mL/min are available, in addition to stainless steel and complete PEEK flow paths.
ProteomeLab™ XL-A/XL-I Protein Characterization System
An important component of lead optimization is the ability to evaluate a drug candidate under concentrated "shelf-life" conditions before it moves into expensive preclinical or clinical trials. The ProteomeLab XL-A/XL-I functions over a wide range of concentration, temperature, ionic strength and pH, delivering more thorough characterization than other methods.
Our unique operating methodology measures the relative change in the distribution of molecular weights, providing an efficient way to measure heterogeneity, stoichiometry and self-associating systems.
Because the ProteomeLab XL-A/XL-I's measurements are based on the first principles of thermodynamics and hydrodynamics, no standards or calibrations are required. As a result, you spend less time on setup, and more time on discovery.
GENOMICS
GenomeLab provides researches with anhanced access to genomic information through our new integrated family of genetic analysis solutions. Designed to innovative, simplify and automate genomics processes, Genomelab enables the identification of new markers of biological, diagnostic and therapeutic interest. Genomelab solutions help researchers identify the differences between normal and diseased states, isolate and purify samples, prepare nucleic acids, and analyze and evaluate genetic material. GenomeLab tools are used in the validation of biomarkers and their association with human identification, specific disease states, as well as in the evaluation of drug efficacy, and may lead to a new generation of standardized diagnostic tests with the promise of delivering personalized medicine.
GenomeLab™ GeXP Genetic Analysis System
Quantitative Gene Expression -- The single best multiplex solution for quantitative, high-hroughput, cost-effective gene expression analysis
Finally, quantitative gene expression that's cost-effective too. The GenomeLab GeXP Genetic Analysis System utilizes a patented, highly multiplexed PCR* approach to quickly and efficiently look at the expression of multiplexed gene sets with greater sensitivity and speed. Building on more than a decade of innovative leadership in laboratory automation and capillary electrophoresis technology, the GenomeLab GeXP clears your pathway to discovery.
Multiple applications for gene expression
- Discovery of Gene Targets
- Pathway Analysis
- Biomarker Discovery
- Microarray Data Validation
- RNAi Studies
- Drug Characterization
- Development of Signatures
- Monitor Gene Regulation
GenomeLab™ SNPstream® Genotyping
SNP genotyping for medium to ultra-high throughput analysis
The GenomeLab SNPstream Genotyping System provides an automated scalable system capable of performing from 4,600 to over 3,000,000 SNP genotypes per day. Combined with multiplexing capabilities, experimental layouts and operational flexibility, this enables you to process a wide range of studies.
DNA Sequencing and Fragment Analysis
CEQ™ 8000 Genetic Analysis System
A
Focus every resource on the science.
Simplify the process and you reduce the chance of error. That's the safeguard built into the CEQ 8000. Developed using Beckman Coulter's extensive experience in laboratory automation and leadership in capillary electrophoresis technology, the CEQ 8000 is a fully automated genetic analysis system. This system automatically fills the capillary array with a patented linear polyacrylamide (LPA) gel, denatures and loads the sample, applies the voltage program, and analyzes the data. Software tools let you rapidly review data quality and even customize automated data assessment. All to ensure unprecedented run-to-run consistency over traditional DNA electrophoresis methods, simplifying the process so you can focus on your research.
- De Novo DNA Sequencing
- Heterozygote Detection
- Confirmatory Sequencing
- Mutation Analysis
- Allele Identification
- SNP Scoring
- Microsatellite Instability
- AFLP Fingerprinting
- Gene Expression
With the CEQ 8000, you can perform virtually all genetic analysis functions with one Gel, one Array and One Software Package.
|
|
|
|
* All trademarks are the property of their respective owners. Where applicable, the PCR process is covered by patents owned by Roche Molecular Systems, Inc., and F. Hoffmann-LaRoche, Ltd.
CEQ™ 8800 Genetic Analysis System
Building on more than a decade of innovative leadership in laboratory automation and capillary electrophoresis technology, the CEQ 8800 introduces a new level of capability in genetic analysis systems over traditional DNA electrophoresis. Integrated with our robust software and chemistries, it delivers specialized and efficient tools that provide continuous, high-confidence results, which puts you on the fast lane to discovery.
The CEQ 8800 is flexible enough to adapt to a broad spectrum of applications, yet easily accessible to a wide range of users.
- De Novo DNA Sequencing
- Heterozygote Detection
- Mutation Analysis
- AFLP® Fingerprinting
- SNP Scoring
- Allele Identification
The CEQ 8800 utilizes dual plates and sample tracking technology to provide an advanced, industry-leading genetic analysis solution. The result is a fully-automated, high-resolution system that adapts well to daily workflow changes in sample type and complexity.
|
|
|
|
|
| The CEQ 8800 Genetic Analysis System has the ability to process and track samples in two 96-well plates. An array of eight capillaries takes full advantage of the 96-well plate format, while reducing the cost and complexity associated with larger arrays. Samples are automatically denaturated on-line prior to electrokinetic injection. |
|
| An integrated bar code reader enables accurate sample tracking and reporting. It also lets you create CEQ sample setup with automated liquid handlers such as the Biomek® series automated laboratory workstation. |
|
| Because the gel is automatically loaded into the capillary array, you're assured of a consistent gel matrix for every run. The modular 20 ml gel cartridge are easily replaced. |
|
| For sample preparation, the Biomek series liquid handlers, as well as Allegra™ and Avanti® series centrifuges are fully compatible with the CEQ 8800. |
|
| On-column, laser-induced fluorescence with auto capillary alignment ensures sensitive and reliable detection. Long-life diode lasers are used to excite infrared dyes, providing higher sensitivity at a fraction of the cost of argon ion lasers. |
Agencourt® Automated Nucleic Acid Isolation And Purification
Agencourt sample preparation reagents, coupled with our Biomek® Series Automated Workstations, provide a top-notch solution for a variety of applications, thus enhancing the productivity, results and economics of your research. Our patented SPRI technology allows for easy automation of nucleic acid purification without sacrificing superior performance. Agencourt SPRI systems include AMPure® for PCR* product purification, CleanSEQ® for dye- terminator removal, Genfind™ for gDNA extraction from whole blood and serum, Orapure™ for buccal cell gDNA isolation, RNAClean® for cDNA purification, CosMCPrep® for simple plasmid purification, RNAdvance™ Tissue for total RNA extraction from tissue and FormaPure™ for total nucleic acid extraction from formalin-fixed, paraffin-embedded tissue samples.
DNA Centrifuge System
The Allegra® 25R High-Performace DNA Centrifuge System performs quick and easy cell harvesting, DNA isolation and post-reaction cleanup with higher performace for standard and deep-well plates.
Perfect for DNA – from Bacteria and Yeast Pelleting - Through Isolation and Purification to Post-Reaction Cleanup
- Hands-free operation with automatic door latch - "Cadillac Close"
- Magnetic rotor ID for precise performance
- Extremely quiet, maintenance-free brushless induction drive
- Operating temperature - from 2º C to 40º C to protect integrity of samples
- Interchangeable rotors accommodate "Cells to Wells" from 0.25 to 500 mL
